Publications 2013

Animal studies

Haase TN, Rasmussen M, Jaksch CAM, Gaarn LW, Petersen CK, Billestrup N, Nielsen JH: Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell. Diabetologia 56:763-773, 2013.

Hou L, Hellgren LI, Kongsted AH, Vaag A, Nielsen MO. Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep. Acta Physiol (Oxf). 2013  Dec 6. [Epub ahead of print]

Hou L, Kongsted AH, Ghoreishi SM, Takhtsabzy TK, Freidrichsen M, Hellgren LI, Kadarmideen HN, Vaag A, Nielsen MO. Pre- and early-postnatal nutrition modify gene and protein expressions of muscle energy metabolism markers and phospholipid fatty acid composition in a muscle type specific manner in sheep. PLoS One 2013;8(6):e65452.

Johnsen L, Kongsted AH, Nielsen MO. Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep. J Endocrinol. 2013;216(3):389-402.

Kongsted AH, Husted SV, Thygesen MP, Christensen VG, Blache D, Tolver A, Larsen T, Quistorff B, Nielsen MO. Pre- and postnatal nutrition in sheep affects  β-cell secretion and hypothalamic control. J Endocrinol. 2013 Oct 4;219(2):159-71. Print 2013 Nov.

Kongsted AH, Tygesen MP, Husted SV, Oliver MH, Tolver A, Christensen VG, Nielsen JH, Nielsen MO. Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model. Acta Physiol (Oxf). 2014 Jan;210(1):84-98. Epub 2013 Mar 22.

Larsen LH, Ørstrup LKH, Hansen SH, Grunnet N, Quistorff B, Mortensen OH. The effect of long-term taurine supplementation and fructose feeding on glucose and lipid homeostasis in Wistar rats. Adv Exp Med Biol. 2013;776:39-50.

Birtwistle M, Khanal P, Kongsted A, Nielsen M, Budge H & Symonds ME (2013): Impact of increased carbohydrate and fat intake during postnatal and juvenile life on gene expression in the sternal fat of sheep. Proc. 37th Int. Union Physiol Sciences, 21-26 July 2013, Birmingham, UK. P927P (abstract).

Human physiological and clinical studies

Produced under network grant “Global maternal and fetal care in prevention of adult non-communicable disease” from the Danish Council for Strategic Research (no. 09-063072)

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V.: A link between GIP and osteopontin in adipose tissue and insulin resistance.  Diabetes. 2013;62(6):2088-94.

Brøns C, Lilleøre SK, Jensen CB, Toubro S, Vaag A, Astrup A. Increased nocturnal fat oxidation in young healthy men with low birth weight: Results from 24-h whole-body respiratory chamber measurements. Metabolism. 2013 May;62(5):709-16.

Friedrichsen M, Poulsen P, Wojtaszewski J, Hansen PR, Vaag A, Rasmussen HB. Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function. PLoS One. 2013;8(2):e56861. Epub 2013 Feb 28.

Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF. Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NHâ‚‚-terminal (sites 2 + 2a) phosphorylation. Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E631-9. Epub 2013 Jan 15

Gillberg L, Jacobsen S, Ribel-Madsen R, Gjesing AP, Boesgaard TW, Ling C, Pedersen O, Hansen T, Vaag A. Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes? PLoS One. 2013;8(3):e58384. Epub 2013 Mar 7.

Gillberg L, Jacobsen SC, Rönn T, Brøns C, Vaag A. PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects - impact of 5days of high-fat overfeeding. Metabolism. 2014 Feb;63(2):263-71. Epub 2013 Oct 23.

Hove KD, Brøns C, Færch K, Lund SS, Petersen JS, Karlsen AE, Rossing P, Rehfeld JF, Vaag A Effects of 12-weeks treatment with a proton pump inhibitor on insulin secretion, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes - A randomised, double-blinded, prospective, placebo-controlled study. Diabetologia. 2013 Jan;56(1):22-30.

Birtwistle M, Khanal P, Kongsted A, Nielsen M, Budge H & Symonds ME. Impact of increased carbohydrate and fat intake during postnatal and juvenile life on gene expression in the sternal fat of sheep. Proc. 37th Int. Union Physiol Sciences, 21-26 July 2013.

Kelstrup L, Damm P, Mathiesen ER, Hansen T, Vaag AA, Pedersen O, Clausen TD. Insulin resistance and impaired pancreatic β-cell function in adult offspring of women with diabetes in pregnancy. J Clin Endocrinol Metab. 2013 Sep;98(9):3793-801. Epub 2013 Jun 24.

Mortensen B, Hingst JR, Frederiksen N, Hansen RW, Christiansen CS, Iversen N, Friedrichsen M, Birk JB, Pilegaard H, Hellsten Y, Vaag A, Wojtaszewski JF. Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1379-90. Epub 2013 Apr 23

Population-based studies

Bisgaard H, Vissing NH, Carson CG, Bischoff AL, Følsgaard NV, Kreiner-Møller E, Chawes BL, Stokholm J, Pedersen L, Bjarnadóttir E, Thysen AH, Nilsson E, Mortensen LJ, Olsen SF, Schjørring S, Krogfelt KA, Lauritzen L, Brix S, Bønnelykke K. Deep phenotyping of the unselected COPSAC2010 birth cohort study. Clin Exp Allergy. 2013 Dec;43(12):1384-94.

Danielsen I, Granström C, Haldorsson T, Rytter D, Hammer Bech B, Henriksen TB, Vaag AA, Olsen SF. Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years. PLoS One. 2013;8(5):e64887.

Danielsen I, Granström C, Rytter D, Hammer Bech B, Brink Henriksen T, Vaag AA, Olsen SF. Does physical activity during pregnancy adversely influence markers of the metabolic syndrome in adult offspring? A prospective study over two decades. J Epidemiol Community Health. 2013;67(8):648-54.

Danielsen I, Granström C, Rytter D, Halldorsson TI, Bech BH, Henriksen TB, Stehouwer CD, Schalkwijk CG, Vaag AA, Olsen SF. Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring. Obesity (Silver Spring). 2013 Oct 25. [Epub ahead of print]

Forsum E, Brantsæter AL, Olafsdottir AS, Olsen SF, Thorsdottir I. Weight loss before conception: A systematic literature review. Food Nutr Res. 2013;57.

Hansen S, Strøm M, Olsen SF, Maslova E, Rantakokko P, Kiviranta H, Rytter D, Bech BH, Hansen LV, Halldorsson TI. Maternal Concentrations of Persistent Organochlorine Pollutants and the Risk of Asthma in the Offspring: Results from a Prospective Cohort with 20-years of Follow-up. Environ Health Perspect 2013.

Hrolfsdottir L, Rytter D, Hammer Bech B, Brink Henriksen T, Danielsen I, Steingrimsdottir L, Olsen SF, and Halldorsson TI. Maternal milk consumption, birth size and adult height of offspring: a prospective cohort study with 20 years of follow-up. Eur J Clin Nutr 2013. [Epub ahead of print].

Knudsen VK, Heitmann BL, Halldorsson TI, Sørensen TI, Olsen SF. Maternal dietary glycaemic load during pregnancy and gestational weight gain, birth weight and postpartum weight retention: a study within the Danish National Birth Cohort. Br J Nutr. 2013;109(8):1471-8.

Kristensen SL, Ramlau-Hansen CH, Ernst E, Olsen SF, Bonde JP, Vested A, Halldorsson TI, Becher G, Haug LS, Toft G. Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction. Hum Reprod. 2013 Dec;28(12):3337-48. Epub 2013 Oct 15.

Maslova E, Strøm M, Olsen SF, Halldorsson TI. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS One 2013. 8(2): e57261.

Maslova E, Strøm M, Oken E, Campos H, Lange C, Gold DR, Olsen SF. Fish intake during pregnancy and the risk of child wheeze, asthma, and allergic rhinitis – longitudinal evidence from the Danish National Birth Cohort. Br J Nutr. 2013;110(7):1313-25.

Maslova E, Hansen S, Jensen CB, Thorne-Lyman AL, Strøm M, Olsen SF. Vitamin D intake in mid-pregnancy and child allergic disease - a prospective study in 44,825 Danish mother-child pairs. BMC Pregnancy and Childbirth 2013;13:199.

Oken E, Guthrie LB, Bloomingdale A, Gillman MW, Olsen SF, Amarasiriwardena CJ, Platek DN, Bellinger DC, Wright RO. Assessment of dietary fish consumption in pregnancy: comparing one-, four- and thirty-six-item questionnaires. Public Health Nutr. 2013 Jul 24:1-11.

Oken E, Guthrie LB, Bloomingdale A, Platek DN, Price S, Haines J, Gillman MW, Olsen SF, Bellinger DC, Wright RO. A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. Nutr J. 2013 Mar 15;12:33.

Rytter D, Bech BH, Halldorsson T, Christensen JH, Schmidt EB, Danielsen I, Henriksen TB, Olsen SF. No association between the intake of marine n-3 PUFA during the second trimester of pregnancy and factors associated with cardiometabolic risk in the 20-year-old offspring. Br J Nutr. 2013:1-10.

Vested A, Ramlau-Hansen CH, Olsen SF, Bonde JP, Kristensen SL, Halldorsson TI, Becher G, Haug LS, Ernst EH, Toft G. Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men. Environ Health Perspect. 2013 Apr; 121(4):453-8, 458e1-5.

CB, Thorne-Lyman AL, Vadgård Hansen L, Strøm M, Odgaard Nielsen N, Cohen A, Olsen SF. Development and validation of a vitamin d status prediction model in danish pregnant women: a study of the Danish national birth cohort. PLoS One 2013; 8(1):e53059.