News 2013

Sheep have a developmental trajectory during fetal life comparable to that of humans, while rats and pigs, which are commonly used species in biomedical research, are much more immature at birth. This makes the sheep a well-suited model for humans in research where consequences of malnutrition in late fetal life is in focus. In the Copenhagen sheep model, we have been able to show that undernutrition in late fetal life can have permanent and adverse consequences for metabolic and endocrine function in adulthood due to a phenomenon termed fetal programming. In contrast, the adverse changes in body functions, which can be induced in response to an unhealthy diet after birth can, however, to an impressive extent be normalized upon diet correction and weight (body fat) loss. Birth thus appears to be a critical set-point for when permanent programming of development and body function can occur.

Her er lammet, som kan afsløre, hvordan gravides kost skader barnet
Ingeniøren 14.03 2013


Centre leader Sjurdur F. Olsen and vice Centre leader Mette Olaf Nielsen speak about the potential consequences of eating an unhealthy diet during pregnancy on the wellbeing of the future child and adult. Some of the results from research conducted at the Centre were presented at a joint symposium  between the CFP and the Early Nutrition project on March 13, 2013 in Copenhagen.

Mother’s unhealthy diet can hurt the children all the way into adulthood (in Danish)
Ingeniøren, March 13, 2013


Research in the CFP has revealed that mother consuming fish at least 2-3 times/week during pregnancy were less like to have children with asthma than women who never ate fish. The articles and video segment elaborate on the findings.

Fish Consumption in Pregnancy: Linked to Less Childhood Asthma
Fats of Life, April, 2013

Mothers consuming fish decreases child’s risk of asthma (in Danish)
Dagens Medicin, March 15, 2013

Pregnant fish consumers have fewer children with asthma (in Danish)
Politiken, March 13, 2013

Pregnant women may prevent asthma by consuming fish (in Danish)
DR.dk, March 13, 2015

Link to SSI press release: http://www.ssi.dk/Aktuelt/Forskningsnyt/2013/2013_03_Fisk%20til%20gravide%20mindsker%20risiko%20for%20astma.aspx

Link to article: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8858185&fulltextType=RA&fileId=S000711451300038X


CFP researchers have previously found that low-fat yoghurt consumption during pregnancy increase risk of later child asthma. Suspecting that artificial sweeteners used in ‘light’ products may be driving the results, they examined artificially-sweetened beverage intake during pregnancy in relation to child asthma. They found that carbonated artificially-sweetened beverage increased risk of child asthma, while sugar-sweetened beverages did not.

Artificially-sweetened carbonated beverages related to asthma (in Danish)
Diabetes Foreningen, March 13, 2013

Artificially-sweetened carbonated beverages in pregnancy may increase risk of asthma in the child (in Danish)
Ingeniøren, March 13, 2013

Link to SSI press release: http://www.ssi.dk/Aktuelt/Forskningsnyt/2013/2013_03_Lightsodavand%20til%20gravide%20og%20mulig%20risiko%20for%20astma.aspx
Link to article: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057261


In the Copenhagen sheep model we have shown that undernutrition in late fetal life can programme for altered function of the thyroid gland, which becomes increasingly manifested as the individual approaches adulthood. Exposure to fetal life undernutrition will increase the risk of hyper thyroidism in adult life, and alters thyroid hormone signaling in target tissues in a tissue specific manner, ie. Upregulated signaling in muscle and liver, but reduced signaling in adipose tissues.

Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep


Low birth weight? Avoid overeating (in Danish)
Diabetes.dk 13.03 2013